Parenchymatous cortical cerebellar atrophy ( chronic atrophy of Purkinje ’ s cells
نویسندگان
چکیده
Parenchymatous cortical cerebellar atrophy (chronic atrophy of Purkinje’s cells). By Harry L. Parker (Section on Neurology) and James W. Kernohan (Section on Pathological Anatomy). From the Mayo Clinic, Rochester, Minnesota. Brain 1933; 56: 191–212. With Subacute spino-cerebellar degeneration occurring in elderly patients. By J. G. Greenfield. From the National Hospital, Queen Square, London. Brain 1934; 57: 161–176
منابع مشابه
Genetic Ablation of PLA2G6 in Mice Leads to Cerebellar Atrophy Characterized by Purkinje Cell Loss and Glial Cell Activation
Infantile neuroaxonal dystrophy (INAD) is a progressive, autosomal recessive neurodegenerative disease characterized by axonal dystrophy, abnormal iron deposition and cerebellar atrophy. This disease was recently mapped to PLA2G6, which encodes group VI Ca(2+)-independent phospholipase A(2) (iPLA(2) or iPLA(2)β). Here we show that genetic ablation of PLA2G6 in mice (iPLA(2)β(-/-)) leads to the ...
متن کاملCerebellar cortical atrophy in a baboon.
These teeth appeared normal on gross, external examination. Jaws are seldom radiographed as a part of the clinical work-up in young dogs suffering from life-threatening renal disease. Even if the jaws were radiographed, standard lateral views cause superimposition of the teeth and identification of distinct mineralized lesions such as the ones seen in these dogs would be difficult. Occlusive de...
متن کاملCerebellar cortical degeneration with ovarian carcinoma.
A case is described of progressive cerebellar degeneration in association with ovarian carcinoma, with nearly 4 years elapsing between the onset of neurological illness and the discovery of the carcinoma. Neither treatment with prednisolone nor surgical removal of the tumour effected any improvement, CAT scanning late in the illness showed marked cerebellar atrophy. Histology at post-mortem sho...
متن کاملAminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.
The contribution of neuronal dysfunction to neurodegeneration is studied in a mouse model of spinocerebellar ataxia type 1 (SCA1) displaying impaired motor performance ahead of loss or atrophy of cerebellar Purkinje cells. Presymptomatic SCA1 mice show a reduction in the firing rate of Purkinje cells (both in vivo and in slices) associated with a reduction in the efficiency of the main glutamat...
متن کاملJuvenile General Paralysis of Insane: a Case Report
Juvenile parenchymatous syphilis, or juvenile general paralysis of insane, first described by Clouston (1877) is among one of the rarer manifestations of congenital syphilis, incidence being about \—1 percent (Stewart, 1933). The infection is transmitted to the fetus via the placenta and the incubation period is about 5-20 years. The intrauterine Spirochaetal infection of the nervous system may...
متن کامل